|
.................................... Search the net .................................... |
|
Paediatric pulmonology and allergology
|
|
|
|
Iveta Skurvydiene, Algirdas Utkus, Daiva Ambrasiene, Arunas Valiulis. Characterization of Lithuanian children with cystic fibrosis according to the data of genotype analysis, sweat test and nasal potential difference measurement Laimute Vaideliene, Jurgis Bojarskas, Jolanta Kudzyte. Links between children's allergy and atopy in their families Kerstin Malmstrom, Guillermo Rodriguez-Gomez, Jeremias Guerra, Cesar Villaran, Andres Pineiror, Lynn X.Wei, Beth C.Seidenberg, Theodore F.Reiss. Oral Montelukast, Inhaled Beclomethasone, and Placebo for Chronic Asthma Aurelija Jucaite, Rimantas Stukas, Arunas Valiulis, Nijole Drazdiene. Hypoxia, Polychlorinated Bilphenyls and Neuromotor Development of Infants Valdone Miseviciene, Jurgis Bojarskas, Vytis Verba. Importance of IgE investigations in wheezing child Nijole Drazdiene, Arunas Valiulis, Saulius Rocka. The Incidence of Diaper Dermatitis Using Pampers and Pampers Lotion Edvardas Danila. Rare case of eosinophilic pneumonia Dane Slapkauskaite, Rita Sopiene, Stase Aciene, Vita Globyte, Violeta Klugiene. Sources of children tuberculosis and endemic seats Algimantas Vingras. Diagnosis and differential diagnosis of bronchial asthma Mohamed bartal, William Busse, Jean bousquet, Edgardo Carrasco, Yu-Zhi Chen, Alexander Chuchalin. Pocket Guide for asthma Management and Prevention. |
|
Characterization of Lithuanian children with cystic fibrosis according to the data of genotype analysis, sweat test and nasal potential difference measurement
Iveta Skurvydiene, Algirdas Utkus, Daiva Ambrasiene, Arunas Valiulis
Patients with cystic fibrosis (CF) show more negative nasal potential difference than healthy children and patients with lung disease, resembling CF. We measured basic nasal potential difference (NPD) in 50 children with CF, 51 children with bronchial asthma and obstructive bronchiolitis, and in 51 healthy school age children. Our data was in line with the data of other investigators: it is obvious that NPD measurement is a valuable CF diagnostic method, that helps to distinguish CF from healthy subjects. "Diseased" controls with bronchial asthma show less negative PD values (a mean PD of -14.6 mV range -7 to -23 mV), than those with obstructive bronchitis (a mean PD of -17.5 mV with range -8.5 to -28 mV), and patients with CF (a mean PD or -32.5 mV with range -7.9 to -42 mV).
|
|
Links between children's allergy and atopy in their families
Laimute Vaideliene, Jurgis Bojarskas, Jolanta Kudzyte
International SPACE programme was set up in Kaunas, and our data confirmed, that children form allergic families were more often ill with allergic diseases in comparison with children from nonallergic families. 32.4 perc. of these 5-7.5 year old children were ill with various allergic diseases: 13.4 perc. had bronchial asthma, 8.5 perc. - hay fever, 14.3 perc. - atopic dermatitis. This percentage is 5 times higher in comparison with population. 2.4 perc. of the examined children had asthma like symptoms, but only 13.4 perc. of them were diagnosed asthma. Examination of possible allergens revealed, that 19.9 perc. of children were allergic to house dust mites, 32.7 perc. - to other aero allergens. Specific IgE to aero allergens was twice more common in elder children than in 20-48 months old. This fact indicates the need of prophylactic measures in toddlers.
|
|
Oral Montelukast, Inhaled Beclomethasone, and Placebo for Chronic Asthma
Kerstin Malmstrom, Guillermo Rodriguez-Gomez, Jeremias Guerra, Cesar Villaran, Andres Pineiror, Lynn X.Wei, Beth C.Seidenberg, Theodore F.Reiss
To compare the clinical benefit of montelukast, a once-daily oral leukotriene receptor antagonist; placebo; and inhaled beclomethasone. Randomized, double-blind, double-dummy, placebo-controlled, parallel-group, 12-week study. 36 sites worldwide. 895 patients 15 to 85 year of age with chronic asthma and an FEV1 50 perc. to 85 perc. of predicted. Montelukast, 10 mg once daily at bedtime; inhaled beclomethasone, 200mg twice daily, administered with a spacer device; or placebo. Primary end points were daytime asthma symptom score ant FEV1. Secondary end points were peak expiratory flow rates in the morning and evening, as-needed b-agonist use, nocturnal awakenings, asthma specific quality of life, and worsening asthma episodes. Over the 12-week treatment period, the average percentage change from baseline in FEV1 was 13.1 perc. with beclomethasone, 7.4 perc. with montelukast, and 0.7 perc. with placebo (p<0.001 for each active treatment compared with placebo; p<0.01 for beclomethasone compared with montelukast). The average change from baseline in daytime symptom score was -0.62 for beclomethasone, -0.41 for montelukast, and -0.17 for placebo (p<0.001 for each active treatment compared with placebo; p<0.01 for beclomethasone compared with montelukast). Each agent improved peak expiratory flow rates and quality of life, reduced nocturnal awakenings and asthma attacks, increased the number of asthma-control days, and decreased the number of days with asthma exacerbations (p<0.001 for each treatment compared with placebo for each point; p<0.01 for beclomethasone compared with montelukast for each end point). Although beclomethasone had a greater mean clinical benefit than montelukast, montelukast had a faster onset of action and a greater initial effect. The two agents caused similar decreases in peripheral blood eosinophil counts (p<0.05 for each agent compared with placebo). Both agents had tolerability profiles similar to that of placebo over the 12-week study. Although beclomethasone had a lager mean effect than montelukast, both drugs provided clinical benefit to patients with chronic asthma. This finding is consistent with the use of these agents as controller medications for chronic asthma.
Ann Intern Med. 1999; 130:487-495
|
|
Hypoxia, Polychlorinated Biphenyls an Neuromotor Development of Infants
Aurelija Jucaite, Rimantas Stukas, Arunas Valiulis, Nijole Drazdiene
Complicated mechanisms of the neonatal encephalopathy are still under extensive investigations worldwide. In relation to traditional perinatal risk factors toxic effect of the environmental contaminants is becoming more apparent. One of the most toxic environmental pollutants are industrial chloroorganic substances. We hypothesized that hypoxia could potentate neurotoxic effect of PCBs. We found relationship between the levels of PCBs in the cord blood and parenchymal changes on the brain ultrasound scans. Long term development of children exposed to the higher doses of PCBs was slightly, but significantly effected. Multiple regression analysis of our data revealed that the effect of PCBs on the contral nervous system of the new-borns was stronger when occurring under perinatal hypoxia. On the contrary, in the group of new-borns with the risk of intrauterine infection, superimposing effect of PCBs was not evident.
|
|
Importance of IgE investigations in wheezing child
Valdone Miseviciene, Jurgis Bojarskas, Vytis Verba
It is now clear that asthma may develop during the first few months of life. Though the most common cause of bronchial wheezing in this age group is thought to be respiratory viral infections, however, recurring episodes of the illness may be associated with exposure to allergens. Laboratory tests for total and specific IgE including a careful history and physical examination could be valuable for the diagnostic of asthma in early childhood. The article presents our data about the sensitization to food and inhalant allergens in wheezing children 0-3 years of age who were investigated for total and specific serum IgE.
|
|
The Incidence of Diaper Dermatitis Using Pampers and Pampers Lotion
Nijole Drazdiene, Arunas Valiulis, Saulius Rocka
Diaper dermatitis is a non-specific term used to describe a wide range of inflammatory reactions of the skin in the area covered by diapers. Congenital skin conditions, contact with the urine and faeces are the main factors, taking place in the development of diaper dermatitis. Urine and faeces change pH of the skin, faecal enzymes affects the integrity. Diaper dermatitis in many cases is associated with the Candida albicans infection. The study was carried out in the Dept. of Neonatology of Vilnius University Hospital on 1998. Pampers and Pampers Lotion diapers were used for the care of 442 newborns. The aim of the study was to evaluate the prevalence and the role of diaper quality in connection to diaper dermatitis. It was found, that the skin of the newborn was dryer and the cases of redden skin were seldom while using Pampers Lotion diapers. The diaper, which inner layer is covered with special lotion with Vaseline, petrolatum and stearyl alcohol provides the better protection against diaper dermatitis.
|
|
Rare case of eosinophilic pneumonia
Edvardas Danila
This article displays the case report of eosinophilic pneumonia. He was ill with pneumonia about 10 months. Chest X-rays show infiltrative shadows. Fibrooptic bronchoscopy revealed multiple bronchial casts. Causes, features and diagnostic methods of eosinophilic pneumonia are discussed.
|
|
Sources of children tuberculosis and endemic seats
Dane Slapkauskaite, Rita Sopiene, Stase Aciene, Vita Globyte, Violeta Klugiene
The morbidity of children tuberculosis is inadequate index to fix the epidemiological situation in region. The quantitative and qualitative changes of endemic seats were compared in region in the period of 20 years. The family members (most often father) were the main source of infection children TB. In the period of 20 years, sources of tuberculosis infection were decreased about two and half times in Radviliskis district. At the same time was decreased its epidemiological significance. Where Siauliai County children had tuberculosis, there were known 41 perc. infection sources of this disease. Usually children were infected by their fathers or other men in their families, who had tuberculosis.
|
|
Diagnosis and differential diagnosis of bronchial asthma
Algimantas Vingras
The syndrom of asthma is defined, the causes of its variability are explained. In diagnosing asthma in small children it is recommended to follow the conclusions of multicentral study of ETAC. The clinical symptoms of asthma are listed emphasizing that wheezing and non-productive cough are the symptoms of many acute respiratory illnesses. The section of differential diagnosis will help physicians to differentiate between atopic-allergic and infectious respiratory illnesses; obstruction of lower airways, acute pneumonia, bronchial asthma and cystic fibrosis with predominating pulmonary affection.
|
|
|
October, 1999, Vol. II, No. 2-3 (p. 411-516)
