Paediatric Pulmonology and Allergology

2003 October, Vol. VI, No. 2 (pp.2215-2221)

A comparative study of the total serum immunoglobulin E level among Lithuanian children with toxocariasis and atopic diseases

Regina Emuzyte, Regina Firantiene, Nijole Suliokiene, Aurelija Dautartiene, Regina Virbaliene

Chan­ges of the to­tal IgE le­vel we­re in­ves­ti­ga­ted in 161 se­rum. Chil­dren we­re di­vi­ded in­to three groups. The first group com­pri­sed 83 pa­tients with ato­pic di­se­a­ses: the se­cond group com­pri­sed 32 pa­tients with to­xo­ca­ria­sis; con­trol group com­pri­sed 46 chil­dren; he­alt­hy and suf­fe­ring from fre­qu­ent vi­ral in­fec­tions, but free of al­ler­gic di­se­a­se and to­xo­ca­ria­sis symp­toms. To­xo­ca­ra se­rop­re­va­len­ce va­lue (po­si­ti­ve ELISA tests ³0,38 ODU) was 12 perc. in chil­dren with ato­pic di­se­a­ses and with an inc­re­a­sed se­rum to­tal IgE le­vel (³100 IU/ml). Our re­sults sho­wed that the se­rum to­tal IgE le­vel, was hig­her in pa­tients with to­xo­ca­ria­sis (1045±172 IU/ml) than in chil­dren with ato­pic di­se­a­ses (427±32 IU/ml; p<0,001). Among the group of chil­dren with to­xo­ca­ria­sis, the se­rum to­tal IgE le­vel was al­so hig­her in tho­se aged abo­ve 12 years (1646±336 IU/ml) than in youn­ger ones (634±129 IU/ml; p<0,001). We conc­lu­ded that in­ves­ti­ga­tions for to­xo­ca­ria­sis are ne­ces­sa­ry in chil­dren with ato­pic di­se­a­se symp­toms, es­pe­cial­ly in the ca­ses when se­rum to­tal IgE le­vel is abo­ve 1000 IU/ml. We su­ges­ted that ato­pic di­se­a­ses rat­her may be al­ter­na­ti­ve to To­xo­ca­ra in­fec­tion than con­co­mi­tant di­se­a­ses.

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