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Paediatric Pulmonology and Allergology
2006 October, Vol. IX, No. 1 (3280-3287)
PECULIARITIES OF SOLUBLE CD23 CONCENTRATION VARIATION DURING ASTHMA REMISSION IN CHILDREN
Irena Pumputiene1, Regina Emuzyte2, Kristina Veriznikoviene3, Ruta Dubakiene4, Vytas Tamosiunas1
1 Vilnius University Instute of Immunology,
2 Vilnius University Children's Hospital,
3 Pasilaiciu Family Medicine Center,
4 Allergologic Center of Vilnius University
Regulation of IgE production and modulation of IgE and their receptors interaction offer the means for immunotherapy of allergic diseases. Soluble CD23 – the low affinity IgE receptor – is a molecule that participates in the regulation of IgE production. We studied the concentration of sCD23 in serum of atopic and nonatopic non-IgE mediated asthmatic children in disease remission and found the correlation between sCD23 and IgE concentration in patient serum. The study group comprised 29 children with atopic asthma (AA), 18 children with nonatopic non-IgE mediated asthma (NAA) and 13 normal control (C) subjects. The level of sCD23 in serum of AA patients was increased significantly (mild AA – 84,65 ± 7,21 ng/ml; p < 0,01; moderate AA – 96,38 ± 5,59 ng/ml; p < 0,001) when compared with C children – 57,49 ± 6,12 ng/ml. There were no statistically significant differences between the serum level of sCD23 results for mild NAA (70,33 ± 6,36 ng/ml), moderate NAA (73,21 ± 6,05 ng/ml) and C children. The sCD23 concentration in serum of AA patients significantly correlated with total IgE in serum of these children. In conclusion, we can take in view, that increased sCD23 concentration could be one of the reasons of increased total IgE concentration in atopic asthmatics serum during remission.